Article

Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease

2021-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Low-flow vascular malformations are congenital overgrowths composed by abnormal blood vessels potentially causing pain, bleeding, and obstruction of different organs. These diseases are caused by oncogenic mutations in the endothelium which result in overactivation of the PI3K/AKT pathway. Lack of robust in vivo preclinical data has prevented the development and translation into clinical trials...

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Literature Corpus work: 06f3a3f7-142c-5ca0-8ff3-46668565a16f
DOI: 10.1101/2021.07.16.452617

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