Article

<i>Crk/Crkl</i> regulates early angiogenesis in mouse embryos by accelerating endothelial cell maturation

2023-07-13

Abstract excerpt

<h4>Rationale</h4> Ubiquitously expressed cytoplasmic adaptors CRK and CRKL mediate multiple signaling pathways in mammalian embryogenesis. They are also associated with cardiovascular defects occurring in Miller-Dieker syndrome and 22q11.2 deletion syndrome, respectively. The embryonic mesoderm contributes to the formation of the cardiovascular system, yet the roles that Crk and Crkl play there are not underst...

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Literature Corpus work: 8c879503-c4ca-5fdf-88fe-2fb127352626
DOI: 10.1101/2023.07.12.548782

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