Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.

doi:10.1111/j.1365-2443.2011.01546.x

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Article

Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2011

Kamijo Hiroshi, Matsumura Yutaka, Thumkeo Dean, Koike Seiichi, Masu Masayuki, Shimizu Yoshihiko, Ishizaki Toshimasa, Narumiya Shuh

Abstract excerpt

Rho-associated coiled-coil-forming protein serine/threonine kinase (ROCK) consisting of two isoforms, ROCK-I and ROCK-II, functions downstream of the small GTPase Rho for assembly of actomyosin bundles. To examine the role of ROCK isoforms in vivo, we previously generated and examined mice deficient in each of the two isoforms individually. Here, we further examined the in vivo role of ROCK isoforms by generating...

Topics

Animals
Female
Gene Expression Regulation, Developmental
Genotype
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Morphogenesis
Mutation
Neovascularization, Pathologic
Phenotype
Yolk Sac
rho-Associated Kinases

Source

Open in PubMed

Identifiers

PMID: 21895889
DOI: 10.1111/j.1365-2443.2011.01546.x

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