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Article

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance.

The Journal of experimental medicine - 7 Mar 2022

Karaman Sinem, Paavonsalo Satu, Heinolainen Krista, Lackman Madeleine H, Ranta Amanda, Hemanthakumar Karthik A, Kubota Yoshiaki, Alitalo Kari

Abstract excerpt

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are quintessential for the development and maintenance of blood and lymphatic vessels. However, genetic interactions between the VEGFRs are poorly understood. VEGFR2 is the dominant receptor that is required for the growth and survival of the endothelium, whereas deletion of VEGFR1 or VEGFR3 was reported to induce vasculature overgrowth....

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Topics

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Share to Blood Vessels
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium

Share to Gene Knockdown Techniques

Share to Neovascularization, Physiologic

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Share to Receptors, Vascular Endothelial Growth Factor

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Source

Open in PubMed Open full text

Identifiers

PMID: 35050301
DOI: 10.1084/jem.20210565
PMCID: PMC8785977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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