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Article

Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.

PloS one - 1 Jan 2015

Chrzanowska-Wodnicka Magdalena, White Gilbert C, Quilliam Lawrence A, Whitehead Kevin J

Abstract excerpt

BACKGROUND: Small GTPase Rap1 has been implicated in a number of basic cellular functions, including cell-cell and cell-matrix adhesion, proliferation and regulation of polarity. Evolutionarily conserved, Rap1 has been studied in model organisms: yeast, Drosophila and mice. Mouse in vivo studies implicate Rap1 in the control of multiple stem cell, leukocyte and vascular cell functions. In vitro, several Rap1...

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Identifiers

PMID: 26714318
DOI: 10.1371/journal.pone.0145689
PMCID: PMC4694701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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