Article
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.
Molecular and cellular biology - 1 Jul 2003
Thumkeo Dean, Keel Jeongsin, Ishizaki Toshimasa, Hirose Masaya, Nonomura Kimiko, Oshima Hiroko, Oshima Masanobu, Taketo Makoto M, Narumiya Shuh
Abstract excerpt
Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. However, in vivo functions of each ROCK isoform remain largely unknown. We generated mice deficient in ROCK-II by gene targeting. ROCK-II(-/-) embryos were found at the expected Mendelian frequency until 13.5 days postcoitum, but approximately 90% died thereafter in...
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