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Article

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

The Journal of cell biology - 2 Jan 2006

Braren Rickmer, Hu Huiqing, Kim Yung Hae, Beggs Hilary E, Reichardt Louis F, Wang Rong

Abstract excerpt

Morphogenesis of a vascular network requires dynamic vessel growth and regression. To investigate the cellular mechanism underlying this process, we deleted focal adhesion kinase (FAK), a key signaling mediator, in endothelial cells (ECs) using Tie2-Cre mice. Targeted FAK depletion occurred efficiently early in development, where mutants exhibited a distinctive and irregular vasculature, resulting in hemorrhage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16391003
DOI: 10.1083/jcb.200506184
PMCID: PMC2063542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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