Article

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

2023-03-07

Abstract excerpt

A major goal of cancer biology is to understand the mechanisms underlying tumorigenesis driven by somatically acquired mutations. Two distinct types of computational methodologies have emerged: one focuses on analyzing clustering of mutations within protein sequences and 3D structures, while the other characterizes mutations by leveraging the topology of protein-protein interaction network. Their insights are larg...

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Literature Corpus work: 1e71ed57-0c24-550e-b08a-df955343297e
DOI: 10.1101/2023.03.06.531441

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