Article
Computed cancer interactome explains the effects of somatic mutations in cancers.
Protein science : a publication of the Protein Society - 1 Dec 2022
Zhang Jing, Pei Jimin, Durham Jesse, Bos Tasia, Cong Qian
Abstract excerpt
Protein-protein interactions (PPIs) are involved in almost all essential cellular processes. Perturbation of PPI networks plays critical roles in tumorigenesis, cancer progression, and metastasis. While numerous high-throughput experiments have produced a vast amount of data for PPIs, these data sets suffer from high false positive rates and exhibit a high degree of discrepancy. Coevolution of amino acid...
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