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Article

A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces.

PLoS computational biology - 1 Oct 2015

Porta-Pardo Eduard, Garcia-Alonso Luz, Hrabe Thomas, Dopazo Joaquin, Godzik Adam

Abstract excerpt

Despite their importance in maintaining the integrity of all cellular pathways, the role of mutations on protein-protein interaction (PPI) interfaces as cancer drivers has not been systematically studied. Here we analyzed the mutation patterns of the PPI interfaces from 10,028 proteins in a pan-cancer cohort of 5,989 tumors from 23 projects of The Cancer Genome Atlas (TCGA) to find interfaces enriched in somatic...

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Identifiers

PMID: 26485003
DOI: 10.1371/journal.pcbi.1004518
PMCID: PMC4616621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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