Article
A pan-cancer catalogue of driver protein interaction interfaces
2015-03-02
Abstract excerpt
Despite their critical importance in maintaining the integrity of all cellular pathways, the specific role of mutations on protein-protein interaction (PPI) interfaces as cancer drivers, though known for some specific examples, has not been systematically studied. We analyzed missense somatic mutations in a pan-cancer cohort of 5,989 tumors from 23 projects of The Cancer Genome Atlas (TCGA) for enrichment on PPI i...
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Identifiers and source
- Literature Corpus work
- 3e75b724-c0a8-5381-b1f9-e53f6b3ab5f7
- DOI
- 10.1101/015883