Article
Comprehensive characterization of protein-protein interactions perturbed by disease mutations.
Nature genetics - 1 Mar 2021
Cheng Feixiong, Zhao Junfei, Wang Yang, Lu Weiqiang, Liu Zehui, Zhou Yadi, Martin William R, Wang Ruisheng, Huang Jin, Hao Tong, Yue Hong, Ma Jing, Hou Yuan, Castrillon Jessica A, Fang Jiansong, Lathia Justin D, Keri Ruth A, Lightstone Felice C, Antman Elliott Marshall, Rabadan Raul, Hill David E, Eng Charis, Vidal Marc, Loscalzo Joseph
Abstract excerpt
Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein-protein interaction (PPI) networks within human cells. Here, we show that disease-associated germline variants are significantly enriched in sequences encoding PPI interfaces compared to variants identified in healthy participants from the projects 1000 Genomes and ExAC....
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