Computed cancer interactome explains the effects of somatic mutations in cancers

Abstract excerpt

Protein-protein interactions (PPIs) are involved in almost all essential cellular processes. Perturbation of PPI networks plays critical roles in tumorigenesis, cancer progression and metastasis. While numerous high-throughput experiments have produced a vast amount of data for PPIs, these datasets suffer from high false positive rates and exhibit a high degree of discrepancy. Coevolution of amino acid positions b...

Topics

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• Deep Learning
• Mutation
• Mutation, Missense
• Neoplasms
• Protein Binding
• Protein Interaction Mapping
• Protein Interaction Maps
• Proteins

Identifiers and source

Literature Corpus work

469700cc-2d50-5679-8774-51ff344c2511

DOI

10.1101/2022.01.21.477304