Article

Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5

2020-12-20

Abstract excerpt

<h4>Summary</h4> Selective vulnerability is a central concept to the myriad of devastating neurodegenerative disorders. Although hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), the degree of involvement lies along a spectrum that we previously defined as AD subtypes revealing distinct clinical correlates. To operationalize heterogeneity of disease spectrum, we classified corticolimb...

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Literature Corpus work: 73594c0e-d85e-5106-8b07-aab01f31e928
DOI: 10.1101/2020.12.18.423469

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