Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.

doi:10.1007/s00401-024-02721-1

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Article

Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.

Acta neuropathologica - 10 Apr 2024

Bhattarai Prabesh, Gunasekaran Tamil Iniyan, Belloy Michael E, Reyes-Dumeyer Dolly, Jülich Dörthe, Tayran Hüseyin, Yilmaz Elanur, Flaherty Delaney, Turgutalp Bengisu, Sukumar Gauthaman, Alba Camille, McGrath Elisa Martinez, Hupalo Daniel N, Bacikova Dagmar, Le Guen Yann, Lantigua Rafael, Medrano Martin, Rivera Diones, Recio Patricia, Nuriel Tal, Ertekin-Taner Nilüfer, Teich Andrew F, Dickson Dennis W, Holley Scott, Greicius Michael, Dalgard Clifton L, Zody Michael, Mayeux Richard, Kizil Caghan, Vardarajan Badri N

Abstract excerpt

The risk of developing Alzheimer's disease (AD) significantly increases in individuals carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist, suggesting the presence of cellular mechanisms that counteract the pathological effects of APOEε4; however, these mechanisms are unknown. We hypothesized that APOEε4 carriers without dementia might carry genetic variations that could...

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PMID: 38598053
DOI: 10.1007/s00401-024-02721-1
PMCID: PMC11006751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.PMID 38598053Read ↗

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