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Article

Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia.

Brain : a journal of neurology - 1 May 2017

Mishra Aniket, Ferrari Raffaele, Heutink Peter, Hardy John, Pijnenburg Yolande, Posthuma Danielle

Abstract excerpt

Genome-wide association studies in frontotemporal dementia showed limited success in identifying associated loci. This is possibly due to small sample size, allelic heterogeneity, small effect sizes of single genetic variants, and the necessity to statistically correct for testing millions of genetic variants. To overcome these issues, we performed gene-based association studies on 3348 clinically identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28387812
DOI: 10.1093/brain/awx066

Genes

APOE
ARHGAP35
SERPINA1
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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