Article

Whole genome analysis in <i>APOE4</i> homozygotes identifies the <i>DAB1-RELN</i> pathway in Alzheimer’s disease pathogenesis

2022-04-28

Abstract excerpt

The APOE -ε4 allele is known to predispose to amyloid deposition and consequently is strongly associated with Alzheimer’s disease (AD) risk. There is debate as to whether the APOE gene accounts for all genetic variation of the APOE locus. Another question which remains is whether APOE -ε4 carriers have other genetic factors influencing the progression of amyloid positive individuals to AD. We conducted a genome-wi...

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Literature Corpus work: 61395d35-e05c-582f-8af1-9c1c9e8fefb1
DOI: 10.1101/2022.04.28.22274418

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