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rs140926439 variant in the Fibronectin FN1 gene protects against Alzheimer’s disease in APOEε4 carriers in the UK Biobank cohort

2024-04-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>A protective genetic variant in the fibronectin FN1 gene reduces the odds of developing AD by up to 70%. This variant, rs140926439, seems to prevent the buildup of excess fibronectin at the blood brain barrier. Increased fibronectin levels are typically observed in people with Alzheimer’s Disease (AD), but the protective variant appears to counteract its effects...

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Literature Corpus work
94757104-0133-5741-9756-4e9f5dc31495
DOI
10.21203/rs.3.rs-4287946/v1
Open publication

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