Article

Resolving genetic linkage reveals patterns of selection in HIV-1 evolution

2019-07-23

Abstract excerpt

Identifying the genetic drivers of adaptation is a necessary step in understanding the dynamics of rapidly evolving pathogens and cancer. However, signals of selection are obscured by the complex, stochastic nature of evolution. Pervasive effects of genetic linkage, including genetic hitchhiking and clonal interference between beneficial mutants, challenge our ability to distinguish the selective effect of individ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd0b926f-ee9e-5a1f-b342-2f9ad417051a
DOI: 10.1101/711861

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resolving genetic linkage reveals patterns of selection in HIV-1 evolutionDOI 10.1101/711861Read

MPL resolves genetic linkage in fitness inference from complex evolutionary histories.Semantic proximity Read

Population genomics of intrapatient HIV-1 evolution.Semantic proximity Read

A de novo approach to inferring within-host fitness effects during untreated HIV-1 infectionSemantic proximity Read

The genetic interaction between HIV and the antibody repertoireSemantic proximity Read

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants.Semantic proximity Read

The effects of linkage on comparative estimators of selection.Semantic proximity Read

Fierce selection and interference in B-cell repertoire response to chronic HIV-1Semantic proximity Read

Estimating linkage disequilibrium and selection from allele frequency trajectories.Semantic proximity Read

Distinguishing driver and passenger mutations in an evolutionary history categorized by interference.Semantic proximity Read

Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen.Semantic proximity Read

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.Semantic proximity Read

Inferring Epistasis from Genetic Time-series Data.Semantic proximity Read