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Article

Inferring Epistasis from Genetic Time-series Data.

Molecular biology and evolution - 7 Oct 2022

Sohail Muhammad Saqib, Louie Raymond H Y, Hong Zhenchen, Barton John P, McKay Matthew R

Abstract excerpt

Epistasis refers to fitness or functional effects of mutations that depend on the sequence background in which these mutations arise. Epistasis is prevalent in nature, including populations of viruses, bacteria, and cancers, and can contribute to the evolution of drug resistance and immune escape. However, it is difficult to directly estimate epistatic effects from sampled observations of a population. At...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36130322
DOI: 10.1093/molbev/msac199
PMCID: PMC9558069

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