Article
Population genomics of intrapatient HIV-1 evolution.
eLife - 11 Dec 2015
Zanini Fabio, Brodin Johanna, Thebo Lina, Lanz Christa, Bratt Göran, Albert Jan, Neher Richard A
Abstract excerpt
Many microbial populations rapidly adapt to changing environments with multiple variants competing for survival. To quantify such complex evolutionary dynamics in vivo, time resolved and genome wide data including rare variants are essential. We performed whole-genome deep sequencing of HIV-1 populations in 9 untreated patients, with 6-12 longitudinal samples per patient spanning 5-8 years of infection. The data...
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