Estimating linkage disequilibrium and selection from allele frequency trajectories.

Abstract excerpt

Genetic sequences collected over time provide an exciting opportunity to study natural selection. In such studies, it is important to account for linkage disequilibrium to accurately measure selection and to distinguish between selection and other effects that can cause changes in allele frequencies, such as genetic hitchhiking or clonal interference. However, most high-throughput sequencing methods cannot...

Topics

• Linkage Disequilibrium
• Gene Frequency
• Selection, Genetic
• Mutation
• High-Throughput Nucleotide Sequencing