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Article

MPL resolves genetic linkage in fitness inference from complex evolutionary histories.

Nature biotechnology - 1 Apr 2021

Sohail Muhammad Saqib, Louie Raymond H Y, McKay Matthew R, Barton John P

Abstract excerpt

Genetic linkage causes the fate of new mutations in a population to be contingent on the genetic background on which they appear. This makes it challenging to identify how individual mutations affect fitness. To overcome this challenge, we developed marginal path likelihood (MPL), a method to infer selection from evolutionary histories that resolves genetic linkage. Validation on real and simulated data sets...

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Identifiers

PMID: 33257862
DOI: 10.1038/s41587-020-0737-3
PMCID: PMC8044047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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