Article

A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection

2019-10-30

Abstract excerpt

In the absence of effective antiviral therapy, HIV-1 evolves in response to the within-host environment, of which the immune system is an important aspect. During the earliest stages of infection, this process of evolution is very rapid, driven by a small number of CTL escape mechanisms. As the infection progresses, immune escape variants evolve under reduced magnitudes of selection, while competition between an i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 09f1facc-5fa2-5fb1-aedf-e78871b861c2
DOI: 10.1101/825117

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A de novo approach to inferring within-host fitness effects during untreated HIV-1 infectionDOI 10.1101/825117Read

Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen.Semantic proximity Read

Resolving genetic linkage reveals patterns of selection in HIV-1 evolutionSemantic proximity Read

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants.Semantic proximity Read

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictableSemantic proximity Read

A binary trait model reveals the fitness effects of HIV-1 escape from T cell responsesSemantic proximity Read

In-vivo mutation rates and fitness landscape of HIV-1Semantic proximity Read

Estimation of an in vivo fitness landscape experienced by HIV-1 under drug selective pressure useful for prediction of drug resistance evolution during treatment.Semantic proximity Read

Distinguishing driver and passenger mutations in an evolutionary history categorized by interference.Semantic proximity Read

Inferring HIV Escape Rates from Multi-Locus Genotype DataSemantic proximity Read

Design of an immunogen containing multidimensionally conserved and immunogenic parts of the HIV proteome.Semantic proximity Read

An evolutionary-based approach to quantify the genetic barrier to drug resistance in fast-evolving viruses: an application to HIV-1 subtypes and integrase inhibitorsSemantic proximity Read

Fierce selection and interference in B-cell repertoire response to chronic HIV-1Semantic proximity Read