Article

Fierce selection and interference in B-cell repertoire response to chronic HIV-1

2018-02-24

Abstract excerpt

During chronic infection, HIV-1 engages in a rapid coevolutionary arms race with the host’s adaptive immune system. While it is clear that HIV exerts strong selection on the adaptive immune system, the characteristics of the somatic evolution that shape the immune response are still unknown. Traditional population genetics methods fail to distinguish chronic immune response from healthy repertoire evolution. Here,...

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Literature Corpus work: fe4b5b7f-c46a-5d77-9fb8-59945882e2a5
DOI: 10.1101/271130

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