Article
Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants.
Viruses - 21 Oct 2015
Hraber Peter, Korber Bette, Wagh Kshitij, Giorgi Elena E, Bhattacharya Tanmoy, Gnanakaran S, Lapedes Alan S, Learn Gerald H, Kreider Edward F, Li Yingying, Shaw George M, Hahn Beatrice H, Montefiori David C, Alam S Munir, Bonsignori Mattia, Moody M Anthony, Liao Hua-Xin, Gao Feng, Haynes Barton F
Abstract excerpt
Within-host genetic sequencing from samples collected over time provides a dynamic view of how viruses evade host immunity. Immune-driven mutations might stimulate neutralization breadth by selecting antibodies adapted to cycles of immune escape that generate within-subject epitope diversity. Comprehensive identification of immune-escape mutations is experimentally and computationally challenging. With current...
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