Article
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.
eLife - 29 Oct 2013
Bartha István, Carlson Jonathan M, Brumme Chanson J, McLaren Paul J, Brumme Zabrina L, John Mina, Haas David W, Martinez-Picado Javier, Dalmau Judith, López-Galíndez Cecilio, Casado Concepción, Rauch Andri, Günthard Huldrych F, Bernasconi Enos, Vernazza Pietro, Klimkait Thomas, Yerly Sabine, O'Brien Stephen J, Listgarten Jennifer, Pfeifer Nico, Lippert Christoph, Fusi Nicolo, Kutalik Zoltán, Allen Todd M, Müller Viktor, Harrigan P Richard, Heckerman David, Telenti Amalio, Fellay Jacques
Abstract excerpt
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48...
Topics
- Alleles
- Genome, Human
- Genome, Viral
- Genome-Wide Association Study
- HIV Infections
- HIV-1
- Histocompatibility Antigens Class I