Article
Distinguishing driver and passenger mutations in an evolutionary history categorized by interference.
Genetics - 1 Nov 2011
Illingworth Christopher J R, Mustonen Ville
Abstract excerpt
In many biological scenarios, from the development of drug resistance in pathogens to the progression of healthy cells toward cancer, quantifying the selection acting on observed mutations is a central question. One difficulty in answering this question is the complexity of the background upon which mutations can arise, with multiple potential interactions between genetic loci. We here present a method for...
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