Article

Proof of concept: Molecular prediction of schizophrenia risk

2017-04-30

Abstract excerpt

<h4>Key Points</h4> <h4>Question</h4> To what extent do global polygenic risk scores (PRS), molecular pathway-specific PRS, complement component (C4) gene expression, MHC loci, sex, and ancestry jointly contribute to risk for schizophrenia-spectrum disorders (SZ)? <h4>Findings</h4> Global polygenic risk for schizophrenia, sex, and their interaction most robustly predict risk in a classification and regression t...

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Literature Corpus work: cc604e34-0b94-571e-8b04-e586cbb03887
DOI: 10.1101/129213

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