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Schizophrenia polygenic risk scores, clinical variables and genetic pathways as predictors of phenotypic traits of bipolar I disorder.

Journal of affective disorders - 1 Jul 2024

Grigoroiu-Serbanescu Maria, van der Veen Tracey, Bigdeli Tim, Herms Stefan, Diaconu Carmen C, Neagu Ana Iulia, Bass Nicholas, Thygesen Johan, Forstner Andreas J, Nöthen Markus M, McQuillin Andrew

Abstract excerpt

AIM: We investigated the predictive value of polygenic risk scores (PRS) derived from the schizophrenia GWAS (Trubetskoy et al., 2022) (SCZ3) for phenotypic traits of bipolar disorder type-I (BP-I) in 1878 BP-I cases and 2751 controls from Romania and UK. METHODS: We used PRSice-v2.3.3 and PRS-CS for computing SCZ3-PRS for testing the predictive power of SCZ3-PRS alone and in combination with clinical variables...

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PMID: 38640977
DOI: 10.1016/j.jad.2024.04.066

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