Article

Development and validation of genomic biotypes for schizophrenia susceptibility from multiple polygenic scores

2025-04-30

Abstract excerpt

Understanding the genetic architecture of schizophrenia (SCZ) is invaluable for the development of personalized treatment. In three independent cohorts, using an automated pipeline, we calculated 413 psychiatry-relevant polygenic scores. Using these scores, machine learning was applied to stratify SCZ patients into two biotypes in FinnGen (n SCZ =7486), and to validate these results in the PsyCourse Study (n SCZ =...

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Literature Corpus work: 4c718b72-23fe-5dfb-b9a0-0554c0553f45
DOI: 10.1101/2025.04.29.25326656

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