Article

Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes

2023-09-02

Abstract excerpt

Psychotic disorders are debilitating conditions with disproportionately high public health burden. Genetic studies indicate high heritability, but current polygenic scores (PGS) account for only a fraction of variance in psychosis risk. PGS often show poor portability across ancestries, performing significantly worse in non-European populations. Pathway-specific PGS (pPGS), which restrict PGS to genomic locations...

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Literature Corpus work: fff21893-fd48-5f76-9c05-0c7b19fd233e
DOI: 10.1101/2023.09.01.23294957

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