Article

Pathway-based polygenic risk scores for schizophrenia and associations with clinical and neuroimaging phenotypes in UK Biobank

2022-07-12

Abstract excerpt

<h4>Background</h4> Schizophrenia is a heritable psychiatric disorder with a polygenic architecture. Genome-wide association studies (GWAS) have reported an increasing number of risk-associated variants and polygenic risk scores (PRS) now explain 17% of the variance in the disorder. There exists substantial heterogeneity in the effect of these variants and aggregating them based on biologically relevant functions...

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Literature Corpus work: 8bf1f2c0-7783-5094-ade5-9d82af3a4757
DOI: 10.1101/2022.07.12.22277553

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