Article

Polygenic risk scores lack prognostic value for adults with severe mental illness

2021-03-22

Abstract excerpt

Schizophrenia (SCZ) is the archetypal severe mental illness and one of the most deeply characterized human genetic traits. Like most common diseases SCZ is highly polygenic, and as such its genetic liability can be summarized at the individual level by a polygenic risk score (PRS). Polygenic risk scores are a cornerstone of the precision medicine vision, as it is widely anticipated they will come to serve as bioma...

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Literature Corpus work: 9f64f861-d6ed-5ca5-8057-674a3a5e5937
DOI: 10.1101/2021.03.19.21253906

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