Article

Investigating Pathway-Partitioned Polygenic Risk Scores for Schizophrenia: Insights into Clinical Variability in Two Patient Cohorts

2026-04-13

Abstract excerpt

<h4>Background</h4> Differences in age of psychosis onset (AOO) in schizophrenia (SCZ) are associated with different illness trajectories. Determining whether AOO differences can be explained by genome-wide or pathway-partitioned polygenic risk for SCZ (SCZ-PRS) may elucidate mechanisms underlying clinical variability. This study examined relationships between AOO, genome-wide SCZ-PRS, and pathway-partitioned SCZ...

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Literature Corpus work: bf452e85-c507-57ba-b1af-b575052f6f3a
DOI: 10.64898/2026.04.11.26349671

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