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Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric Disorders

1 Mar 2025

Abstract excerpt

Schizophrenia polygenic risk scores (SCZ PRS) have emerged as important tools for modulating factors not only in schizophrenia but also in major psychiatric disorders, such as major depression (MDD) and bipolar disorder (BD). Initially developed to capture the common variant risk for SCZ, accumulating evidence highlights the transdiagnostic impact of SCZ PRS on clinical severity, treatment response, and...

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Genetic Associations and Epidemiology
Mental Health Research Topics
Schizophrenia research and treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40098640
DOI: 10.2147/ndt.s514514

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