Article

Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotype

2025-12-08

Abstract excerpt

Alzheimer’s disease (AD) risk is strongly shaped by age, sex, and the apolipoprotein E ε4 ( APOE4 ) allele—the strongest genetic risk factor for late-onset AD. While each factor has been studied independently, their combined impact on cellular and molecular processes remains unclear. Here, we used single-nucleus RNA sequencing (snRNA-seq) to profile hippocampal cell states in a sex-balanced cohort of human APOE4...

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Literature Corpus work: b9c6b02c-3574-57ee-8e1a-bdb7e4462fce
DOI: 10.64898/2025.12.03.691944

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