Article

Brain Region-Specific Oligodendrocyte States Highlight Mitochondrial Gene Upregulation and Loss of Canonical Identity Signatures in Alzheimer’s Disease

2026-01-14

Abstract excerpt

Oligodendrocyte dysfunction and heterogeneity are emerging as key contributors to Alzheimer’s disease (AD) pathology, though cellular mechanisms remain unclear. Using single-nucleus RNA sequencing across three cortical regions from the same individuals, we identified region- and disease-specific transcriptomic changes, including increased mitochondrial genes and loss of cell type signatures. These results highligh...

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Literature Corpus work: 67b992cd-c029-5b72-9f59-7e44093ac8f2
DOI: 10.64898/2026.01.14.699226

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