Article

The Landscape of Sex- and APOE Genotype-Specific Transcriptional Changes in Alzheimer’s Disease at the Single Cell Level

2024-12-05

Abstract excerpt

Alzheimer’s disease (AD) is the most common form of dementia, with approximately two-thirds of AD patients are females. Basic and clinical research studies show evidence supporting sex-specific differences contributing to the complexity of AD. There is also strong evidence supporting sex-specific interaction between the primary genetic risk factor of AD, APOE4 and AD-associated neurodegenerative processes. Recent...

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Literature Corpus work: 03015e10-93d7-57e5-82ab-181d9e077ed0
DOI: 10.1101/2024.12.01.626234

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