Article

Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutation

2022-09-12

Abstract excerpt

Activation-induced cytidine deaminase (AID) somatically hypermutates the immunoglobulin heavy chain variable region (IGHV) gene to create the antibody diversity required to resist infections. This hypermutational process involves many pathways including transcription, DNA structural change and repair. While many of the proteins involved have been identified, their relative abundance, organization and regulation ha...

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Literature Corpus work: cc27adef-120e-57a3-a252-f281509ce52a
DOI: 10.1101/2022.09.08.507190

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