Article
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2012
Kato Lucia, Begum Nasim A, Burroughs A Maxwell, Doi Tomomitsu, Kawai Jun, Daub Carsten O, Kawaguchi Takahisa, Matsuda Fumihiko, Hayashizaki Yoshihide, Honjo Tasuku
Abstract excerpt
Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. Along with...
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