A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.

doi:10.1084/jem.20171738

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Article

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.

The Journal of experimental medicine - 5 Mar 2018

Álvarez-Prado Ángel F, Pérez-Durán Pablo, Pérez-García Arantxa, Benguria Alberto, Torroja Carlos, de Yébenes Virginia G, Ramiro Almudena R

Abstract excerpt

Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering mutations or chromosome translocations, with major implications for oncogenic transformation. However, understanding the specificity of AID has proved extremely challenging. We have sequenced...

Topics

Animals
Base Sequence
Cytidine Deaminase
DNA Damage
DNA Mismatch Repair
High-Throughput Nucleotide Sequencing
Lymphoma
Mice
Mutation
Somatic Hypermutation, Immunoglobulin

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Identifiers

PMID: 29374026
DOI: 10.1084/jem.20171738
PMCID: PMC5839764

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