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Article

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.

The Journal of experimental medicine - 5 Mar 2018

Álvarez-Prado Ángel F, Pérez-Durán Pablo, Pérez-García Arantxa, Benguria Alberto, Torroja Carlos, de Yébenes Virginia G, Ramiro Almudena R

Abstract excerpt

Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering mutations or chromosome translocations, with major implications for oncogenic transformation. However, understanding the specificity of AID has proved extremely challenging. We have sequenced...

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Identifiers

PMID: 29374026
DOI: 10.1084/jem.20171738
PMCID: PMC5839764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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