Epigenomic Modifications Mediating Antibody Maturation

doi:10.3389/fimmu.2018.00355

Article

Epigenomic Modifications Mediating Antibody Maturation

26 Feb 2018

Abstract excerpt

Epigenetic modifications, such as histone modifications, DNA methylation status, and non-coding RNAs (ncRNA), all contribute to antibody maturation during somatic hypermutation (SHM) and class-switch recombination (CSR). Histone modifications alter the chromatin landscape and, together with DNA primary and tertiary structures, they help recruit Activation-Induced Cytidine Deaminase (AID) to the immunoglobulin...

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