Article

Activation-induced cytidine deaminase, an antibody diversification enzyme, interacts with chromatin modifier UBN1 in B-cells

2022-12-21

Abstract excerpt

Activation-induced cytidine deaminase (AID) is the key mediator of antibody diversification in activated B-cells by the process of somatic hypermutation (SHM) and class switch recombination (CSR). Targeting of AID to the Ig genes requires transcription (initiation and elongation), and enhancers as well as its interaction with numerous factors. Furthermore, the HIRA chaperone complex, a regulator of chromatin archi...

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Literature Corpus work: 55929c33-2b8a-5d75-8754-e09756de2829
DOI: 10.21203/rs.3.rs-2379831/v1

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