Article

Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape

2022-05-21

Abstract excerpt

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA). Transcription is essential for SHM and AID target genes harbor activating chromatin marks and RNA polymerase II (Pol II) stalling, leading to the model that these features favor higher rates of mutagenesis. However, whethe...

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Literature Corpus work: 97bc6de1-bd04-5f15-b740-e319e8b61e87
DOI: 10.1101/2022.05.21.492925

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