Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity

Abstract excerpt

Antibodies, fundamental to immune defense, derive their diversity primarily from the intricate rearrangement of variable (V), diversity (D), and joining (J) gene segments. Traditionally, D genes in the forward (5’-3’) direction contribute to this diversity by rearranging with V and J segments. However, the existence and significance of inverted D genes (InvDs), which are D genes oriented in the inverted (3’-5’) di...

Topics

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• Alleles
• Genes, Immunoglobulin
• Genes, Immunoglobulin Heavy Chain
• Germ-Line Mutation
• Immune Cell Function and Interaction
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

7fa07758-e51f-5d76-9809-3552f8eae8de

DOI

10.1101/2024.04.26.591287