Article
Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.
Leukemia - 1 Jul 2021
Hübschmann Daniel, Kleinheinz Kortine, Wagener Rabea, Bernhart Stephan H, López Cristina, Toprak Umut H, Sungalee Stephanie, Ishaque Naveed, Kretzmer Helene, Kreuz Markus, Waszak Sebastian M, Paramasivam Nagarajan, Ammerpohl Ole, Aukema Sietse M, Beekman Renée, Bergmann Anke K, Bieg Matthias, Binder Hans, Borkhardt Arndt, Borst Christoph, Brors Benedikt, Bruns Philipp, Carrillo de Santa Pau Enrique, Claviez Alexander, Doose Gero, Haake Andrea, Karsch Dennis, Haas Siegfried, Hansmann Martin-Leo, Hoell Jessica I, Hovestadt Volker, Huang Bingding, Hummel Michael, Jäger-Schmidt Christina, Kerssemakers Jules N A, Korbel Jan O, Kube Dieter, Lawerenz Chris, Lenze Dido, Martens Joost H A, Ott German, Radlwimmer Bernhard, Reisinger Eva, Richter Julia, Rico Daniel, Rosenstiel Philip, Rosenwald Andreas, Schillhabel Markus, Stilgenbauer Stephan, Stadler Peter F, Martín-Subero José I, Szczepanowski Monika, Warsow Gregor, Weniger Marc A, Zapatka Marc, Valencia Alfonso, Stunnenberg Hendrik G, Lichter Peter, Möller Peter, Loeffler Markus, Eils Roland, Klapper Wolfram, Hoffmann Steve, Trümper Lorenz, Küppers Ralf, Schlesner Matthias, Siebert Reiner
Abstract excerpt
B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mechanisms is implicated in lymphomagenesis, but the mutational processes are poorly understood. By performing whole genome and transcriptome sequencing of 181 germinal center derived B-cell lymphomas (gcBCL) we...
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