Article

Human antibody heavy chain variable region exon interacts with 3’ regulatory region to form a stable somatic hypermutation center

2026-07-22

Abstract excerpt

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) of immunoglobulin heavy chain (HC) variable region exons in germinal center (GC) B cells, allowing selection of affinity-matured B cell receptors. The V(D)J exon location is ‘‘privileged’’ for SHM targeting of diverse sequences within it. In analogy to the related HC class switch recombination center, we proposed that cohesin-mediate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10edf74f-af98-5279-8782-da7c5e448a15
DOI: 10.64898/2026.07.20.739632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human antibody heavy chain variable region exon interacts with 3’ regulatory region to form a stable somatic hypermutation centerDOI 10.64898/2026.07.20.739632Read

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.Semantic proximity Read

Contribution of the IGCR1 regulatory element and the 3 <i>’Igh</i> CBEs to Regulation of <i>Igh</i> V(D)J RecombinationSemantic proximity Read

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphomaSemantic proximity Read

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Semantic proximity Read

AID in Antibody Diversification: There and Back Again.Semantic proximity Read

Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.Semantic proximity Read

Somatic hypermutation mechanisms during lymphomagenesis and transformation.Semantic proximity Read

Activated mature B cells undergo enforced Sµ-3'RRrec in the λ-c-MYC mouse modelSemantic proximity Read

Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutationSemantic proximity Read

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.Semantic proximity Read

Overlapping hotspots in CDRs are critical sites for V region diversification.Semantic proximity Read

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopesSemantic proximity Read