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Article

Identification of core DNA elements that target somatic hypermutation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2012

Kohler Kristin M, McDonald Jessica J, Duke Jamie L, Arakawa Hiroshi, Tan Sally, Kleinstein Steven H, Buerstedde Jean-Marie, Schatz David G

Abstract excerpt

Somatic hypermutation (SHM) diversifies the V region of Ig genes and underlies the process of affinity maturation, in which B lymphocytes producing high-affinity Abs are generated and selected. SHM is triggered in activated B cells by deamination of deoxycytosine residues mediated by activation-induced deaminase (AID). Whereas mistargeting of SHM and AID results in mutations and DNA damage in many non-Ig genes,...

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Identifiers

PMID: 23087403
DOI: 10.4049/jimmunol.1202082
PMCID: PMC3664039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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