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Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway

1 Jul 2010

Abstract excerpt

Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone modifications, and widespread histone replacement. Here, we show that DNA demethylation in the mouse PGCs is mechanistically linked to the appearance of single-stranded DNA (ssDNA) breaks and the activation of the base excision repair...

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PMID: 20595612
DOI: 10.1126/science.1187945

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